Endocrine Abstracts

Androgen receptor (AR) signaling is critical at all stages of prostate cancer including chemically castrated late-stage forms of the disease. How the AR can initiate transcription in the absence of androgens has been proposed to occur through several mechanisms including the production of constitutively active androgen receptor variants. Lacking a ligand binding domain, these variants are intrinsically resistant to all clinically approved AR antagonists and have been found to ...

Family history of thyroid disease (Karger 2010) and family history of goiter (Singer 2011, Knudsen 2003, Gebremichael 2020) were found to be associated with risk of goiter though some did not observe this association (Phitayakorn 2006). On participants of the Isparta Menopause and Health (IMH) Study, we measured TSH (n=1099) and thyroid sonographic parameters (n=994) including TV, thyroid nodularity (TN) and heterogeneity (TH). Health related factors and hist...

Irisin is a myokine induced by exercise, that converts white fat tissue to brown fat tissue, thereby increasing thermogenesis and providing energy expenditure. The aim of this study is to determine the relationships between serum irisin levels and glucose and lipid parameters in obese children with and without non-alcoholic fatty liver disease (NAFLD). A total of 60 pubertal obese children (31 F, 29 M, age range: 11–18 yrs.) were included in this study. 30 of Whom had NAF...

Hypertrophic osteoarthropathy (HOA) is a syndrome characterized with proliferation of bones at the distal parts of extremities. Clubbing, periostitis of tubular bones and non-inflammatory arthritis of lower extremities are commonly seen as a part of this syndrome.66 years old male patient was admitted to our hospital with painful swelling of his left lower extremity for 2 months. He denies any other systemic symptoms such as fever and weight loss. He had...

Introduction: The thyroid is generally resistant to infections due to its encapsulated location, high iodine concentration, hydrogen peroxide production, and high levels of blood and lymphoid circulation therefore acute suppurative thyroiditis is rarely seen. The most common agents are Staphilococcus and Streptococcus. In this case we present acute suppurative thyroiditis caused by Burkholdeira cepacia, that is a rare infectious agent in adults.Case: 34 ...

Introduction: Thyroglossal duct cyst (TDC) is a developmental abnormality of the thyroid gland. Malignancy arising from this duct is very rare. Due to embryological remnants of thyroid tissue located in the TDC, all malignant tumors which develop in the thyroid gland may also develop in the TDC. In case of malignancy, the most probable diagnosis is papillary thyroid carcinoma.Case report: We present a 27-year-old female patient complaining of a midline n...

Introduction: Glucocorticoids, even endogenous or exogenous, suppress the inflammatory response therefore they are the most preferred treatment options in inflammatory diseases. Persistent hypercortisolism induces lymphopenia and lymphoid tissue atrophy. Excessive endogenous hypercortisolism might mask the active inflammatory disease. Rebound immune modulation may occur after Cushing’s syndrome (CS) remission, leading to the new onset of autoimmune diseases.<p class="...

Introduction: Lymphocytic hypophysitis is a rare endocrine disease involving lymphocytic infiltration and chronic pituitary inflammation. It may result in significant morbidity by loss of pituitary functions and neurological deficits. Pituitary abscess is another rare disease which may be associated with underlying parasellar pathology. Here, we report a case of lymphocytic hypophysitis diagnosed with a pituitary abscess and recurrent suprasellar involvement after surgery....

Background: Acromegaly is associated with increased risk of coronary atherosclerosis and cardiovascular mortality. Changes in coagulation and fibrinolysis markers in acromegalic patients have been shown to indicate increase in the risk of developing cardiovascular disease. Mean platelet volume (MPV) is a marker of platelet functions and activity, and increased MPV is an independent risk factor of myocardial infarction and thrombotic events. In this study, we examined the level...

Introduction: Differentiated thyroid carcinoma (DTC) rarely represents with distant organ metastasis. Cerebral metastasis is seen in 0.4–1.2% of patients with distant organ metastasis. There are only 14 patients of DTC with pituitary metastasis reported in the literature. Here, we report a papillary thyroid carcinoma (PTC) patient represented with pituitary metastasis.Case: A 68-year-old male patient has admitted to our hospital with a growing tumou...